Journal article
Colon and rectal cancer survival by tumor location and microsatellite instability: The colon cancer family registry
AI Phipps, NM Lindor, MA Jenkins, JA Baron, AK Win, S Gallinger, R Gryfe, PA Newcomb
Diseases of the Colon and Rectum | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
Abstract
Background: Cancers in the proximal colon, distal colon, and rectum are frequently studied together; however, there are biological differences in cancers across these sites, particularly in the prevalence of microsatellite instability. Objective: We assessed the differences in survival by colon or rectal cancer site, considering the contribution of microsatellite instability to such differences. Design: This is a population-based prospective cohort study for cancer survival. SETTINGS: This study was conducted within the Colon Cancer Family Registry, an international consortium. Participants were identified from population-based cancer registries in the United States, Canada, and Australia. P..
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Grants
Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by the National Cancer Institute, National Institutes of Health (RFA CA-95-011) and through cooperative agreements with members of the Colon Cancer Family Registry and Principal Investigators. Collaborating centers include the Australian Colorectal Cancer Family Registry (5U24CA097735, M.A.J., A.K.W.), the Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (5U24CA074800, N.M.L.), the Ontario Registry for Studies of Familial Colorectal Cancer (5U24CA074783, S.G., R.G.), the Seattle Colon Cancer Family Registry (5U24CA074794, P.A.N.), and the University of Southern California (5U24CA074799, J.A.B.). This publication was also supported by National Cancer Institute career grant K05CA152715 (to P.A.N.) and training grant R25CA94880 (to A.I.P.).